Kynurenic Acid in Plasma and Endometrium in Bitches with Pyometra

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Endometritis and pyometra in bitches: a review

Endometritis-pyometra is the most frequent and complex pathology in domestic bitches. This process involves several immunological changes as well as molecular mechanisms responsible for inflammation in the female uterus. The various clinical stages of pyometra are associated with various symptoms. In this review, several aspects are described, including physiological and pathological mechanisms...

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Pyometra in Bitches Induces Elevated Plasma Endotoxin and Prostaglandin F2α Metabolite Levels

Endotoxemia in bitches with pyometra can cause severe systemic effects directly or via the release of inflammatory mediators. Plasma endotoxin concentrations were measured in ten bitches suffering from pyometra with moderately to severely deteriorated general condition, and in nine bitches admitted to surgery for non-infectious reasons. Endotoxin samples were taken on five occasions before, dur...

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Serum IL-6 and IL-10 concentrations in bitches with pyometra undergoing ovariohysterectomy

BACKGROUND Pyometra is a serious bacterial infection of the uterus affecting female dogs and manifests as an accumulation of pus in the uterine lumen. The aim of the study was to assess changes in serum interleukin (IL)-6 and IL-10 concentrations in bitches with pyometra undergoing ovariohysterectomy. FINDINGS Blood samples were collected from healthy bitches (controls) and bitches with pyome...

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Kynurenic acid and schizophrenia.

In recent years the "dopamine (DA) hypothesis of schizophrenia", has been modified into a more diversified view where an attenuated glutamatergic neurotransmission is believed to participate in the pathogenesis of the disease. Thus, schizophrenia may be regarded as a glutamate deficiency disorder. Kynurenic acid (KYNA) is an endogenous glutamate antagonist with a preferential action at the glyc...

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ژورنال

عنوان ژورنال: Inflammation

سال: 2012

ISSN: 0360-3997,1573-2576

DOI: 10.1007/s10753-012-9527-5